Mid-level Biochemist salary in San Francisco, CA
Based on 125 certified H-1B filings at DOL wage level II in the San Francisco-Oakland-Fremont, CA metro area, FY2025–FY2026. Includes South San Francisco, Berkeley, Foster City, San Carlos, Pleasanton.
Salary range
| Percentile | Salary |
|---|---|
| 10th | $107,802 |
| 25th | $112,882 |
| 50th (median) | $115,357 |
| 75th | $130,000 |
| 90th | $148,186 |
Salary by year
Median salary
Filings per year
Show as table
| Fiscal year | Median | P25 | P75 | Filings |
|---|---|---|---|---|
| FY2020 | $89,523 | $89,523 | $100,100 | 71 |
| FY2021 | $106,920 | $99,902 | $120,000 | 60 |
| FY2022 | $110,000 | $104,853 | $120,000 | 76 |
| FY2023 | $112,680 | $111,072 | $122,802 | 64 |
| FY2024 | $115,000 | $110,000 | $130,500 | 56 |
| FY2025 | $115,000 | $112,882 | $125,000 | 81 |
| FY2026 | $122,400 | $115,357 | $138,050 | 44 |
Cost of living
San Francisco's median mid-level Biochemist salary of $115,357 is worth about $99,800 at national average prices.
Source: BEA Regional Price Parities, 2024 (U.S. = 100; San Francisco = 115.6).
Compared with all workers here
All Biochemists and Biophysicists in the San Francisco, CA area earned a median of $165,050 in May 2025 (1,380 employed). The H-1B median here is $115,357, 30% lower.
Source: U.S. Bureau of Labor Statistics, OEWS metropolitan area estimates. BLS wages include some incentive pay; H-1B figures are base salary.
Employers filing at this level
| Employer | Median | Filings |
|---|---|---|
| Gilead Sciences | $112,882 | 18 |
| MRL San Francisco | too few | 6 |
| Howard Hughes Medical Institute | too few | 5 |
| Arcus Biosciences | too few | 4 |
| CZ Biohub SF | too few | 4 |
| Denali Therapeutics | too few | 4 |
| Genentech | too few | 4 |
| Nurix Therapeutics | too few | 4 |
| BioMarin Pharmaceutical | too few | 3 |
| Calico Life Sciences | too few | 3 |
Employers with at least 2 filings here. Median shown at 10+ filings.
By experience level
| Wage level | Median | Filings |
|---|---|---|
| Entry-level · Level I | $99,306 | 52 |
| Mid-level · Level II | $115,357 | 125 |
| Senior · Level III | $141,898 | 70 |
| Expert · Level IV | $175,000 | 25 |
Median shown when a level has at least 10 filings.
Minimum H-1B salary by level
| Wage level | Prevailing wage (most common) | Median offered salary | Filings |
|---|---|---|---|
| Entry-level · Level I | $88,670 | $99,306 | 52 |
| Mid-level · Level II | $112,882 | $115,357 | 125 |
| Senior · Level III | $137,072 | $141,898 | 70 |
| Expert · Level IV | $168,438 | $175,000 | 25 |
The prevailing wage is the minimum an employer must pay for this job and area. Amounts vary by county within a metro and by wage source.